SCIENTIFIC ARTICLES

 

Optimization of hydroxyl radical scavenging activity of exo-polysaccharides from Inonotus obliquus in submerged fermentation using response surface methodology.
Chen H, Xu X, Zhu Y. J Microbiol Biotechnol. 2010 Apr;20(4):835-43.PMID: 20467262 [PubMed – indexed for MEDLINE]

Lu X, Chen H, Dong P, Fu L, Zhang X. J Sci Food Agric. 2010 Jan 30;90(2):276-80.PMID: 20355042 [PubMed – indexed for MEDLINE]

Anti-inflammatory effects of Inonotus obliquus in colitis induced by dextran sodium sulfate.

Choi SY, Hur SJ, An CS, Jeon YH, Jeoung YJ, Bak JP, Lim BO. J Biomed Biotechnol. 2010;2010:943516. Epub 2010 Mar 10. Review.PMID: 20300439 [PubMed – indexed for MEDLINE]

Antioxidant activities of extracts and subfractions from Inonotus Obliquus.

Liang L, Zhang Z, Wang H. Int J Food Sci Nutr. 2009;60 Suppl 2:175-84. Epub 2009 Jul 1.PMID: 19585318 [PubMed – in process]

Anti-inflammatory effect of Inonotus obliquus, Polygala senega L., and Viburnum trilobum in a cell screening assay.

Van Q, Nayak BN, Reimer M, Jones PJ, Fulcher RG, Rempel CB. J Ethnopharmacol. 2009 Sep 25;125(3):487-93. Epub 2009 Jul 3.PMID: 19577624 [PubMed – indexed for MEDLINE]

Progress of research on Inonotus obliquus.

Zhong XH, Ren K, Lu SJ, Yang SY, Sun DZ. Chin J Integr Med. 2009 Apr;15(2):156-60. Epub 2009 Apr 29. Review.PMID: 19407959 [PubMed – indexed for MEDLINE]

Oxidative stress response of Inonotus obliquus induced by hydrogen peroxide.

Zheng W, Zhao Y, Zhang M, Wei Z, Miao K, Sun W. Med Mycol. 2009 Dec;47(8):814-23.PMID: 19184774 [PubMed – in process]

Comparative study of antioxidant activity and antiproliferative effect of hot water and ethanol extracts from the mushroom Inonotus obliquus.

Hu H, Zhang Z, Lei Z, Yang Y, Sugiura N. J Biosci Bioeng. 2009 Jan;107(1):42-8.PMID: 19147108 [PubMed – indexed for MEDLINE]

Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract.

Ham SS, Kim SH, Moon SY, Chung MJ, Cui CB, Han EK, Chung CK, Choe M. Mutat Res. 2009 Jan 10;672(1):55-9. Epub 2008 Oct 17.PMID: 18992843 [PubMed – in process]

Chaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells.

Youn MJ, Kim JK, Park SY, Kim Y, Kim SJ, Lee JS, Chai KY, Kim HJ, Cui MX, So HS, Kim KY, Park R. World J Gastroenterol. 2008 Jan 28;14(4):511-7.PMID: 18203281 [PubMed – indexed for MEDLINE]Free PMC Article

New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus.

Lee IK, Kim YS, Jang YW, Jung JY, Yun BS. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6678-81. Epub 2007 Oct 25.PMID: 17980585 [PubMed – indexed for MEDLINE]

Antioxidant small phenolic ingredients in Inonotus obliquus (persoon) Pilat (Chaga).

Nakajima Y, Sato Y, Konishi T. Chem Pharm Bull (Tokyo). 2007 Aug;55(8):1222-6.PMID: 17666849 [PubMed – indexed for MEDLINE

Analysis of aqueous extract of Inonotus obliquus.

Mazurkiewicz W. Acta Pol Pharm. 2006 Nov-Dec;63(6):497-501.PMID: 17438866 [PubMed – indexed for MEDLINE]

Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus.

Hyun KW, Jeong SC, Lee DH, Park JS, Lee JS. Peptides. 2006 Jun;27(6):1173-8. Epub 2005 Nov 11.PMID: 16289471 [PubMed – indexed for MEDLINE]

Chaga mushroom extract inhibits oxidative DNA damage in human lymphocytes as assessed by comet assay.

Park YK, Lee HB, Jeon EJ, Jung HS, Kang MH. Biofactors. 2004;21(1-4):109-12.PMID: 15630179 [PubMed – indexed for MEDLINE]

Antioxidant effect of Inonotus obliquus.

Cui Y, Kim DS, Park KC. J Ethnopharmacol. 2005 Jan 4;96(1-2):79-85.PMID: 15588653 [PubMed – indexed for MEDLINE]
Zjawiony JK. J Nat Prod. 2004 Feb;67(2):300-10. Review.PMID: 14987072 [PubMed – indexed for MEDLINE]
[The nature of melanin pigments from some micro- and macromycetes]
Babitskaia VG, Shcherba VV. Prikl Biokhim Mikrobiol. 2002 May-Jun;38(3):286-91. Russian. PMID: 12068581 [PubMed – indexed for MEDLINE]
[Physicochemical properties of melanins produced by Inonotus obliquus(“chagi”) in the nature and the cultivated fungus]
Kukulianskaia TA, Kurchenko NV, Kurchenko VP, Babitskaia VG. Prikl Biokhim Mikrobiol. 2002 Jan-Feb;38(1):68-72. Russian. PMID: 11852571 [PubMed – indexed for MEDLINE]
[Melanin complex of the fungus Inonotus obliquus]
Babitskaia VG, Shcherba VV, Ikonnikova NV. Prikl Biokhim Mikrobiol. 2000 Jul-Aug;36(4):439-44. Russian. PMID: 10994193 [PubMed – indexed for MEDLINE]
[Effects of bioglycans from birch fungus Inonotus obliquus on the electrical activity of cells from the cardiac venous sinus of the frog]
Golovko VA. Biull Eksp Biol Med. 1999 Sep;128(9):264-6. Russian. No abstract available. PMID: 10560041 [PubMed – indexed for MEDLINE]

The effect of aqueous extracts from Inonotus obliquus on the mitotic index and enzyme activities.

Rzymowska J. Boll Chim Farm. 1998 Jan;137(1):13-5.PMID: 9595828 [PubMed – indexed for MEDLINE]

Antimitotic activity of aqueous extracts of Inonotus obliquus.

Burczyk J, Gawron A, Slotwinska M, Smietana B, Terminska K. Boll Chim Farm. 1996 May;135(5):306-9.PMID: 8942059 [PubMed – indexed for MEDLINE]

Fungi in Khanty folk medicine.

Saar M. J Ethnopharmacol. 1991 Feb;31(2):175-9.PMID: 2023426 [PubMed – indexed for MEDLINE]

Effect of the extracts from fungus Inonotus obliquus on catalase level in HeLa and nocardia cells.

Jarosz A, Skórska M, Rzymowska J, Kochmańska-Rdest J, Malarczyk E. Acta Biochim Pol. 1990;37(1):149-51.PMID: 2087905 [PubMed – indexed for MEDLINE]
[Aqueous extracts of Inonotus obliquus vel. Poria obliqua in the diagnosis of leukemias.]
KRAUSS-ZAKI J. Postepy Hig Med Dosw. 1962 Sep-Oct;16:855-9. Polish. No abstract available. PMID: 14035596 [PubMed – indexed for MEDLINE]
[Nature and origin of water-soluble pigment complex formed by Inonotus obliquus.]
SHIVRINA AN, LOVIAGINA EV, PLATONOVA EG. Biokhimiia. 1959 Jan-Feb;24(1):67-72. Russian. No abstract available. PMID: 13628806 [PubMed – indexed for MEDLINE]
[Pharmacological and biological characteristics of Inonotus obliquus.]
BAZYLEVA NN, BOLOTKINA LI, LASKINA EM, OSVETIMSKAIA NP, SMIRNOVA LI. Farmakol Toksikol. 1958 Sep-Oct;21(5):89-90. Russian. No abstract available. PMID: 13609697 [PubMed – OLDMEDLINE]

Farmakol Toksikol. 1958 Sep-Oct;21(5):89-90. Russian. No abstract available. PMID: 13609697 [PubMed – OLDMEDLINE]

Alves, R. E., et al. 2002. Camu camu (Myrciaria dubia Mc Vaugh): a rich natural source of vitamin C. Proc. Interamer. Soc. Trop. Hort. 46:11-13.

Babitskaya, V. G,, Scherba, V. V., Ikonnikova, N.V., Bisko, N.A., and N.Y. Mitropoiskaya. 2002. Melanin complex from medicinal mushroom Inonotus obliquus (Pers:Fr.) Pilat (Chaga) (Aphyllophoromycetidae). Int. J. Med. Mushrooms. 4:139-45.

Babitskaya, V. G,, Scherba, V. V., Ikonnikova, N.V., Bisko, N.A., and N.Y. Mitropoiskaya. 2002. Melanin complex from medicinal mushroom Inonotus obliquus (Pers:Fr.) Pilat (Chaga) (Aphyllophoromycetidae). Int. J. Med. Mushrooms. 4:139-45.

Bobek, P., Ozdin, L., and I. Kajaba. 1997. Dose-dependent hypocholesterolemic effect of oyster mushroom (Pleurotus ostreatus) in rats. Physiol Res. 47:327-329.

Bobek, P. and S. Galbavy. 1999. Hypocholesteremic and antiatherogenic effect of oyster mushroom (Pleurotus osteratus) in rabbits. Nahrung. 43:339-342.

Burczyk, J., Gawron, A. Slotwinska, M., Smietana, B., and K. Terminiska. 1996. Antimitotic activity of aqueous extracts of Inonotus obliquus. Boll. Chim. Farm. 135:306.

Chang, S. T. 1999. Global impact edible and medicinal mushrooms on human welfare in the 21st century: non-green evolution. Int. J. Med. Mushr. 1:1-7.

Chen, C., Zheng, W., Gao, X., Xiang, X., Sun, D., Wei, J., and C. Chu. 2007. Aqueous extract of Inonotus obliquus (Fr.) pilat (Hymenochaetaceae) significantly inhibits the growth of sarcoma 180 by inducing apoptosis. American Journal of Pharmacology and Toxicology. 2:10-17.

Chihara, G., Maeda, Y., Sasaki, T. and F. Fukuoaka. 1969. Inhibition of mouse sarcoma 180 by polysaccharides from Letin us eodes (Berk.) Nature. 222:687.

Chorvathova, V., et al. 1993. Effect of oyster fungus on glycemia and cholesterolaemia in rats with insluin-dependent diabetes. Physiol. Res. 42:175-179.

Cui, Yo, Kim, D. S., and K. C. Park. 2005. Antioxidant effects of Inonotus Oblique. J. Ethnopharmacol. 96:79-85.

de Sa, M. S., et al. 2009. Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciprum and in vivo in P. Berghel-infected mice. Parisitol. Res. Jul;105:275-279.

Ham, S. S., et al. 2003. Antimutagenic and cytotoxic effects of ethanol extract from the Inonotus obliquus. J. Korean Soc. Food Sci. Nutr. 32:1088-94.

Hawksworth, D. L. 2001. Mushrooms: the extent of the unexplored potential. Int. J. Med. Mushr. 2:1-9.

Hossain, S., et al. 2003. Dietary mushroom (Pleurotus ostreatus) ameliorates atherogenic lipid in hypercholesterolaemic rats. Clin. Exp. Pharmacol. Physiol. 30:470-475.

Hyun, K. W., Jeong, S. C., Lee, D. H., Park, J. S., and J. S. Lee. 1996. Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus. Boll. Chim. Farm. 135:306-309.

In-Kyoung, L., Young-Sook, K., Yoon-Woo, J., Jin-Young, J., and Y. Bong-Suk. 2007. New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus. Bioorganic & Medicinal Chemistry Letters. 17:6678-6681.

Jeremias, I., et al. 2004. Cell death induction by betulinic acid, ceramide, and TRAIL in primary glioblastoma multiforme cells. Acta Neurochirurgica. 146:721-729.

Kharazmi, A. 2008. Laboratory and preclinical studies on the anti-inflammatory and anti-oxidant properties of rosehip powder—identification and characterization of the active component GOPO. Osteoarhritis and Cartilage. 16:55-57.

Kim, B. K., Shin, G.G., Jeong, B.S., and J.Y. Cha. 2001. Cholesterol lowering effect of mushrooms powder in hyperlipidemic rats. J. Korean Soc. Food Sci. Nutr. 30:510-515.

Kim, Y. O., et al. 2005. Immuno-stimulatory effect of the endopolysaccharide produced by submerged culture of Inonotus obliquus. Life Sci. 77:2438-56.

Koyama, T., Yeunhwa, G., and T. Akira. 2008. Fungal medicine, Fuscoporia obliqua, as a traditional herbal medicine, in vivo testing and medicinal effects. Asian Biomedicine. 2:459-469.

Kraus-Zaki, J. 1957. (In Polish) ACTH jako czynnik hydrolizujacy kwasy dezoksyrybonukleinowe w zastosowaniu do bada cytoenzymatycznych. Haematologica. 1:48-50.

Krauss-Zaki, J. 1962. Correspondence: Digestion of Cell Nucleus by Enzymes. Blood Journal. 19:527.

Lindequist, U., Niedermeyer, T. H. J., and W-D Julich. 2005. The pharmacological potential of mushrooms. Institute of Pharmacy, Greifswald, Germany.

Lull, C., Wichers, H. J., and H. F. J. Savelkoul. 2005. Antiinflammatory and immunomodulating properties of fungal metabolites (In) Mediators of Inflammation. Hindawi Publishing Corp.

McCord, J. M. and I. Fridovich. 1988. Superoxide dismutase: the first twenty years (1968-1988). Free Radic. Biol. Med. 5(5-6):363-369.

Mothana, R. A. A., Awadh, N. A. A., Jansen, R.,Wegner, U., Mentel, R., and U. Lindequist. 2003. Antiviral lanostanoid triterpenes from the fungus Ganoderma pfeifferi BRES Fitoteraia. 74:483-485.

Muller, F. L., et al. 2006. Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy. Free Radic. Biol. Med. 40:1993-2004.

Najafzadeh, M., et al. 2007. Chaga mushroom extract inhibits oxidative DNA damage in lymphocytes of patients. Biofactors. 31:191-200.

Nasar-Abbas, S. M. and A. Kadir Haikman. 2004. Antimicrobial effect of water extract of sumac (Rhus coriaria L.) on the growth of some food borne bacteria, including pathogens. J. Food Micro. 10:1016.

Nicolson, G. L., et al. 2000. Diagnosis and integrative treatment of intercelluar bacterial infections in chronic fatigue and fibromyalgia syndromes, GulfWar Illness, and rheumatoid arthritis and other chronic illnesses. Clin. Prac. Alt. Med. 1:92.

Nicolson, G. L. 2002. Co-infections in fibromyalgia syndrome, chronic fatigue syndrome, and other chronic illnesses. National Fibromyalgia Partnership—Fibromyalgia Frontiers. 10:5-9; 27-28.

Papas, A. M. (ed). 1999. Anitoxidant Status, Diet, Nutrition, and Health. Boca Raton: CRC Press. Park,Y. M., et al. 2005. In vivo and in vitro anti-inflammatory and antinociceptive effects of the methanol extract of Inonotus obliquus. J. Ethnopharmacol. 101:120-128.

Park,Y. M., et al. 2007. In vivo and in vitro anti-inflammatory and antinociceptive effects of the methanol extract of Inonotus obliquus. J. Med. Food. 10:80-90.

Rein, E., Kharazmi, A., and K. Winther. 2004. A herbal remedy, Hyben Vital (stand. Powder of Rosa canina fruits) reduces pain and improves general welbeing in patients with osteoarthritis- a double-blind, placebo controlled randomized trial. Phytomedicine. 11:383.

Rzymowska, J. 1996. The effect of aqueous extracts from Inonotus obliquus on the mitotic index and enzyme activities. Boll Chim. Farm. 135:306-309.

Scott, Cyril. 1944. Health, Diet, and Common Sense. London: the Homeopathic Publishing Co.

Shin, Y., Tamai, Y., and M. Terazawa. 2000. Chemical constituents of Inonotus obliquus sclerotium. Eurasian Journal of Forest Research. 1:43-50.

Shivrina, A.N. 1967. Chemical characteristics of compounds extracted from Inonotus obliquus. Chem. Abstr. 66:17271-17279.

Takada, Y. and B. B. Aggarawal. 2003. Betulinic acid suppresses carcinogen-induced NF-kB activation through inhibition of lkappaB alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9. Journal of Immunology. 171:3278.

Wang, H., Gao, J., and T. B. Ng. 2000. A new lectin with highly potent antihepatoma and antisarcoma activities from the oyster mushroom Pleurotus ostreatus. Biochem. Biophys. Res. Commun. 275:810-816.

Wick, W., Grimmel, C., Wagenknecht, B., Dichgans, J. and M. Weller. 1999. Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reaction oxygen species, and caspase processing. J. Pharmacol. Exp. Ther. 289:1306-1312.

Winther, K., Apel, K. and G. Thamsborg. 2005. A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knew and hip osteoarhritis: A randomized, double-blind placebo controlled trial. Scand J. Rheumatol. 34:302.

Joo, J.I., Kim, D.H., Yun, J.W. 2010. “Extract of Chaga mushroom (Inonotus obliquus) stimulates 3T3-L1 adipocyte differentiation.” Phytother Res. 24 (11):1592-9. doi: 10.1002/ptr.3180.

Ko, S.K., Jin, M., Pyo, M.Y. 2011. “Inonotus obliquus extracts suppress antigen-specific IgE production through the modulation of Th1/Th2 cytokines in ovalbumin-sensitized mice.” J Ethnopharmacol. 137 (3):1077-82. E-pub July 28, 2011.

Najafzadeh, M., Reynolds, P.D., Baumgartner, A., Jerwood, D., Anderson, D. 2007 “Chaga mushroom extract inhibits oxidative DNA damage in lymphocytes of patients with inflammatory bowel disease.” Mol Cells. 31 (2):165-73. E-pub Dec. 22, 2010.

Park, Y.K., Lee, H.B., Jeona, E-J., Jungb, H.S., Kang, M.H. 2004. “Chaga mushroom extract inhibits oxidative DNA damage in human lymphocytes as assessed by comet assay” BioFactors 21:109-112.

Stamets, P., 2008. U.S. Patent Application # 12/284,646. “Antiviral and Antibacterial Activity from Medicinal Mushrooms.” Filed September 24, 2008.

Won, D.P., Lee, J.S., Kwon, D.S., Lee, K.E., Shin, W.C., Hong, E.K. 2011. “Immunostimulating activity by polysaccharides isolated from fruiting body of Inonotus obliquus.” Mol Cells 31(2):165-73. E-pub 22 Dec. 2010.

The Cure is in the Forest – Dr. Cass Ingram

Chaga: King of the Medicinal Mushrooms – David Wolfe, Pierre Beaumir, and Ramiz Jaad (2012)

Benefits of Daily Chaga Use!

An Immune System Modulator- supported by beta glucans and polysacharides help to regulate the immune system
Anti-aging- super antioxidants reduces oxidation and slows the aging process
Anti-bacterial- protects against the growth of bacteria
Anti-fungal- protects against fungal infections
Anti-microbial- inhibits the growth of microorganisms
Anti-candida- protects against yeast infections
Anti-viral- helps to protect against viral infections
An Adaptogen- adapts to the body and provides it with what it needs
High in antioxidants- help to fight free-radicals which can cause cell damage
Reduces Inflammation
Increases Energy

Why Wildcrafted Siberian Chaga Extract™ is the best in the world!

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